At the beginning of seventeenth century, the Clarisses of the Monastery of Santa Maria Donnaregina decided to build a new baroque church. Works for the construction of this new religious building - called Santa Maria Regina Nuova - began in 1617. Ascending the magnificent staircase you enter the nave of the church, lined with polychrome marble with once seventeenth-century frescoed vault with the Gloria della Vergine.
On presbytery is a fresco of the young Francesco Solimena, which represents the miracle of the roses of St. Francesco and, beside the high altar, there are the latest paintings by Luca Giordano. Inside the church there is the Museo Diocesano di Napoli (Diocesan Museum of Naples), which contains works of great value: the Immacolata Concezione of lorrainer Charles Mellin, dating 1646, the Santificazione di Francesco, rare iconography of Solimena: in the sacristy there is the Madonna con Bambino by Massimo Stanzione.
